Chronic infections are active or hidden infections that continually exist in the body and create a response from the immune system that may include inflammation. While inflammation can be one healing tool of the immune system, long-term inflammation can be harmful. Infections that result in chronic inflammation may contribute in part to multiple health issues, including:
- Metabolic disorders such as insulin resistance and diabetes.1,2
- Certain cancers.3,4
- Digestive and intestinal conditions such as stomach ulcers, inflammatory bowel disease, and irritable bowel syndrome.5-8
- Brain disorders such as Alzheimer’s disease and Parkinson’s disease.9-11
Enhancing the immune system’s function can be an important strategy for helping to reduce the chance and impact of infection and any resulting sustained inflammation. Lifestyle factors and habits have a large effect on the immune system and are important to consider when supporting overall immune health.
Nutrition & Anti-Inflammatory Foods
Food and nutrition impact health and well-being. Diets that contain inflammatory foods such as processed foods and foods higher in sugar and sodium have been linked to higher rates of different chronic conditions such as metabolic syndrome and obesity, as well as heart disease and other cardiovascular diseases.12-15 But diets such as the Mediterranean diet that prioritize more anti-inflammatory and nutrient-dense foods such as plants, healthy fats, and whole grains help support optimal health and reduced inflammation in the body.16-18
Phytonutrients from fruits and vegetables are one example of anti-inflammatory and protective antioxidant compounds that support the immune system. In addition, a variety of herbs and spices such as black pepper, turmeric, and saffron provide not only bursts of flavor in meals but also provide concentrated amounts of vitamins, minerals, phytonutrients, and other anti-inflammatory compounds.19
Studies indicate that people who eat more plant foods have reduced risk of chronic diseases such as cardiovascular disease, type 2 diabetes, and cancer.20 And the phytonutrients from plant foods and spices come in all different colors; therefore, eating a rainbow of colors each day may be one way to easily increase anti-inflammatory food intake.
The Functional Medicine Approach
In functional medicine, healthcare practitioners consider potential underlying issues related to health concerns and conditions such as immune dysfunction, chronic infections, and inflammation. A personalized, whole-body approach to immune health in addition to lifestyle-based treatment strategies are foundational in the functional medicine model. Practitioners collaborate with patients to develop tailored therapies that are most beneficial to a patient’s health condition and their overall health goals.
The functional medicine approach involves the whole patient, including their lifestyle choices and preferences to assess the body’s complex processes and to personalize treatment strategies while supporting them in their health journey.
Use the link below to find a functional medicine practitioner near you and learn more about chronic infections, chronic inflammation, and how lifestyle-based therapies that include nutritional strategies may be appropriate in a personalized health intervention.
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REFERENCES
- Lee YS, Olefsky J. Chronic tissue inflammation and metabolic disease. Genes Dev. 2021;35(5-6):307-328. doi:10.1101/gad.346312.120
- Perakakis N, Harb H, Hale BG, et al. Mechanisms and clinical relevance of the bidirectional relationship of viral infections with metabolic diseases. Lancet Diabetes Endocrinol. 2023;11(9):675-693. doi:10.1016/S2213-8587(23)00154-7
- Drnovsek J, Homan M, Zidar N, Smid LM. Pathogenesis and potential reversibility of intestinal metaplasia – a milestone in gastric carcinogenesis. Radiol Oncol. 2024;58(2):186-195. doi:10.2478/raon-2024-0028
- Infectious agents. National Cancer Institute. Updated March 4, 2019. Accessed November 22, 2024. https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents
- Suzuki S, Kusano C, Horii T, Ichijima R, Ikehara H. The ideal Helicobacter pylori treatment for the present and the future. Digestion. 2022;103(1):62-68. doi:10.1159/000519413
- Axelrad JE, Cadwell KH, Colombel JF, Shah SC. Systematic review: gastrointestinal infection and incident inflammatory bowel disease. Aliment Pharmacol Ther. 2020;51(12):1222-1232. doi:10.1111/apt.15770
- Berumen A, Edwinson AL, Grover M. Post-infection irritable bowel syndrome. Gastroenterol Clin North Am. 2021;50(2):445-461. doi:10.1016/j.gtc.2021.02.007
- Liao L, Su BB, Xu SP. Helicobacter pylori infection and small intestinal bacterial overgrowth: a systematic review and meta-analysis. BMC Microbiol. 2023;23(1):386. doi:10.1186/s12866-023-03063-w
- Doulberis M, Kotronis G, Gialamprinou D, et al. Alzheimer's disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement. Int J Neurosci. 2021;131(3):289-301. doi:10.1080/00207454.2020.1738432
- Lotz SK, Blackhurst BM, Reagin KL, Funk KE. Microbial infections are a risk factor for neurodegenerative diseases. Front Cell Neurosci. 2021;15:691136. doi:10.3389/fncel.2021.691136
- Mercado G, Kaeufer C, Richter F, Peelaerts W. Infections in the etiology of Parkinson's disease and synucleinopathies: a renewed perspective, mechanistic insights, and therapeutic implications. J Parkinsons Dis. 2024;14(7):1301-1329. doi:10.3233/JPD-240195
- Fabiani R, Naldini G, Chiavarini M. Dietary patterns and metabolic syndrome in adult subjects: a systematic review and meta-analysis. Nutrients. 2019;11(9):2056. doi:10.3390/nu11092056
- Kopp W. How western diet and lifestyle drive the pandemic of obesity and civilization diseases. Diabetes Metab Syndr Obes. 2019;12:2221-2236. doi:10.2147/dmso.s216791
- Mazidi M, Shivappa N, Wirth MD, et al. Dietary inflammatory index and cardiometabolic risk in US adults. Atherosclerosis. 2018;276:23-27. doi:10.1016/j.atherosclerosis.2018.02.020
- Li J, Lee DH, Hu J, et al. Dietary inflammatory potential and risk of cardiovascular disease among men and women in the U.S. J Am Coll Cardiol. 2020;76(19):2181-2193. doi:10.1016/j.jacc.2020.09.535
- Ojo O, Ojo OO, Zand N, Wang X. The effect of dietary fibre on gut microbiota, lipid profile, and inflammatory markers in patients with type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials. Nutrients. 2021;13(6):1805. doi:10.3390/nu13061805
- Sánchez-Rosales AI, Guadarrama-López AL, Gaona-Valle LS, Martínez-Carrillo BE, Valdés-Ramos R. The effect of dietary patterns on inflammatory biomarkers in adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2022;14(21):4577. doi:10.3390/nu14214577
- Koelman L, Egea Rodrigues C, Aleksandrova K. Effects of dietary patterns on biomarkers of inflammation and immune responses: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr. 2022;13(1):101-115. doi:10.1093/advances/nmab086
- Mandal D, Sarkar T, Chakraborty R. Critical review on nutritional, bioactive, and medicinal potential of spices and herbs and their application in food fortification and nanotechnology. Appl Biochem Biotechnol. 2023;195(2):1319-1513. doi:10.1007/s12010-022-04132-y
- Wang Y, Liu B, Han H, et al. Associations between plant-based dietary patterns and risks of type 2 diabetes, cardiovascular disease, cancer, and mortality – a systematic review and meta-analysis [published correction appears in Nutr J. 2024;23(1):6. doi:10.1186/s12937-023-00891-4]. Nutr J. 2023;22(1):46. doi:10.1186/s12937-023-00877-2