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Autoimmunity: A Functional Medicine Guide

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Autoimmune disease affects hundreds of millions of people worldwide, and diagnoses are increasing.1

In collaboration with Cleveland Clinic, this first-of-its-kind eBook details a comprehensive Functional Medicine approach to evaluating and treating patients with autoimmune conditions. Including a range of toolkit items, from an autoimmune intake form to patient education across a range of lifestyle factors, this eBook provides the tools and information to improve patient outcomes.

Like Functional Medicine itself, this Functional Medicine (FM) Guide does not intend to replace the standard of care but to enhance it. Therefore, this guide is designed especially for treating those patients who have not realized the best achievable outcomes while being treated according to established guidelines. While suitable for patients ranging from the prodromal to long-standing diagnoses, this guide applies specific Functional Medicine evaluation and treatment protocols to expand upon the current guidelines in the safest, most personalized manner possible.

This guide includes evidence-based recommendations for patient care. The foundation for the level of evidence analysis was the American Academy of Family Physicians’ SORT taxonomy.2 Care considerations are also summarized in flow charts.

Prerequisite Knowledge

A working knowledge of the Functional Medicine model is necessary for effective application of this guide. We strongly recommend attending Applying Functional Medicine in Clinical Practice before purchasing this eBook, as that course provides an introduction to the Functional Medicine model and its foundational tools.

Technical Specifications

This is an eBook requiring a tablet, e-reader, or computer with appropriate software to read. The book is delivered as a .mobi and .epub file, so e-reader software is required. Download and access instructions for supported devices are included.

The book is delivered alongside a link to the over 100 downloadable toolkit items referenced in this Guide.


Contributing Committee

Keith Berndtson, MD, Bette Bischoff, MD, RD, Elizabeth Boham, MD, RD, Leonard Calabrese, DO, Jill Carnahan, MD, Mary Ellen Chalmers, DMD, John Cline, MD, Joel Dahms, MS, Ruth DeBusk, RD, PhD, Kara Fitzgerald, ND, Nora Galil, MD, Carla Guggenheim, DO, Robert Hedaya, MD, Bruce Hoffman, MD, M. Elaine Husni, MD, MPH, Mark Hyman, MD, Carrie Ingrisano, MSN, FNP,  Dan Lukaczer, ND, Neil Nathan, MD, Maryclaire O’Neill, DO, Rich Panico, MD, Sonia Rapaport, MD, Varsha Rathod, MD, Robert Rountree, MD, P. Michael Stone, MD, MS, Tom Sult, MD

Additional Information


EBook End User License Agreement (EULA)

It is important that you read this document before accessing or downloading Autoimmunity: A Guide for Functional Medicine Practitioners (“eBook”) provided by The Institute for Functional Medicine (“IFM”). By downloading or installing a copy of the eBook, you acknowledge and agree that you are binding yourself to the terms of this EULA. If you do not “accept” these terms, then you are not licensed to use the eBook, and you must destroy any downloaded copies thereof.

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  • Under no circumstances, including negligence, shall IFM be liable for any incidental, special, indirect or consequential damages arising out of or relating to this License. Some jurisdictions do not allow the limitation of incidental or consequential damages, so this limitation may not apply to you. In no event shall IFM’s total liability to you for all damages exceed the amount of fifty US dollars ($50.00).
  • This Agreement constitutes the entire understanding between IFM and Consultant regarding the subject matter hereof. There are no other representations or understandings. This Agreement supersedes any prior or contemporaneous understandings between Consultant and IFM. Both parties agree to cooperate and execute any additional documents or instruments that may be necessary to implement the terms of this Agreement).

IFM Clinical Practice Toolkit Terms and Conditions


[1] Cooper GS, Bynum ML, Somers EC. Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun. 2009;33(3-4):197-207. doi:10.1016/j.jaut.2009.09.008

[2] Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. J Am Board Fam Pract. 2004;17(1):59-67.

Suggested Citation

Luby R, Sennett C, Hanaway P, et al, eds. Autoimmunity: A Functional Medicine Guide. Institute for Functional Medicine; 2019. Accessed [include date]. https://www.ifm.org/learning-center/autoimmunity-functional-medicine-guide/

Supported Devices

Supported devices:
  1. PC/Mac
  2. iPad/iPhone
  3. Android
  4. Kindle
  5. Nook & other eReader devices

Complete download and access instructions are delivered along with the eBook and supporting toolkit materials.