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Food and Toxins: Safe Grilling and Frying Methods

When it comes to food, much attention is paid to “what” we eat—whether it’s organic, gluten-free, whole, or processed—and rightfully so; the nutritional value of the foods we consume significantly influences our trajectory of health and disease. And yet, the effects of foods extend beyond their inherent nutritional value. The way food is prepared changes its healthfulness.

Grilling & Cancer Risk

Small amounts of grilled meat are likely just fine to consume, but for people with a history of cancer and/or high consumption, there are some red flags to consider. Research suggests that meat, including beef, pork, poultry, or fish, may form carcinogenic chemicals called heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) when charred or cooked over high heat, as on a grill.1 As well, when fat drips into the grill, the resulting flames can cover food with PAHs.2

In animal studies, these chemicals have been found to damage DNA, causing nucleotide alterations and gross chromosomal aberrations, increasing the risk of cancers of the mammary glands, lung, colon, and prostate.3-7 A number of epidemiological studies have evaluated the association of well-done meat intake and meat carcinogen exposure with cancer risk. As summarized in a 2009 review, these studies suggest that high exposure to meat carcinogens, particularly HCAs, may increase the risk of human cancer.8 A 2011 population-based case-control study suggests that the consumption of red meat cooked at high temperatures is associated with increased risk of advanced, but not localized, prostate cancer.9 However, other studies have found no association with risks of colorectal10 or prostate cancer.11

Learn More About Biotransformation Pathways and Toxic Exposures

In 2015, an independent panel of experts convened by the International Agency for Research on Cancer (IARC) determined the consumption of red meat to be “probably carcinogenic to humans,” based largely on data from the epidemiologic studies and on the strong evidence from mechanistic studies.12 However, IARC did not conclude that HCAs and PAHs were associated with cancer incidence.12

HCAs are formed when amino acids and creatine react at high temperatures.1 PAHs are formed when fat and juices from meat grilled directly over a heated surface or open fire drip onto the surface or fire, causing flames and smoke. The smoke contains PAHs that then adhere to the surface of the meat. PAHs can also be formed during other food preparation processes, such as the smoking of meats.1

Inhalation may also contribute to PAH risk, dependent on the degree of exposure.13 As well, PAHs may be absorbed through the skin. Interestingly, in a 2018 case study in China on the carcinogenicity of PAHs, researchers found that in the case of barbeque fumes, dermal absorption was a more important pathway for intake of low-molecular-weight PAHs than inhalation.14

What steps can patients take to improve the healthfulness of grilled meats? The IFM Toolkit contains “A Guide to Grilling Foods,” which can be freely downloaded and printed for distribution in the office. It includes some of the following information:

  • Go Lean: Instead of grilling fatty burgers or sausages (that can produce PAHs when fat hits a flame), opt for grass-fed steak, chicken, or fish. Further, removing the skin from poultry before cooking will reduce HCA formation.
  • Avoid Charring & Trim Meat: Rotate meat frequently to allow the center to fully cook without overheating the surface. Remove any charred portions of meat, and refrain from using gravy made from meat drippings.
  • Use Foil: Wrap meat in foil to prevent fat from dripping into the hot coals. Also, foil-wrapping fruits and veggies can protect them from high heat and the harmful effects of grilled meats (which may accompany them). 
  • Use Marinades: Acidic rubs and marinades may help break down some of the muscle in the meat and reduce the number of HCAs on your plate.
Health Effects of Perfluorooctanoic Acid (PFOA)

Per- and polyfluoroalkyl substances (PFAS) are a group of chemicals that have been used in a variety of everyday products since the 1950s, including perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), GenX, and others.15 PFOA and PFOS have been the most extensively produced and studied of these chemicals. Both chemicals are persistent in the environment and in the human body, and some studies suggest that exposure to PFAS may lead to adverse human health effects, including: 

  • Decreased fertility
  • Hormonal changes
  • Increased cholesterol
  • Weakened immune system response
  • Increased cancer risk
  • Growth and learning delays in infants and children15

PFOAs have been used for a variety of purposes, including nonstick pans for cooking (like Teflon).16 (In the US, Teflon pans have been PFOA-free since 2013). However, this is not the case with all non-stick pans produced worldwide, and PFOAs may also persist in the environment, particularly in soil and water.16

animal studies

At high doses, in mammalian animal studies, the ammonium salt of PFOA produced altered weights of the liver, kidney, thymus, and spleen; hepatotoxicity; endocrine and immune effects; and, in offspring, growth retardation and delayed sexual maturation.17,14

In its 2005 draft risk assessment, the US Environmental Protection Agency concluded that evidence was suggestive that PFOA is carcinogenic in humans;18 in a 2006 review of that risk assessment, three of the four members of the EPA scientific advisory board concluded more strongly that PFOA was “likely to be carcinogenic in humans.”19

However, the relevance of animal (primarily rodent) data for humans is controversial:20

“In animals, PFOA is a strong peroxisome proliferator in the liver, and this proliferation has been shown to alter lipids, liver enzymes, and liver size,” writes Steenland et al in Environmental Health Perspectives. “Peroxisome proliferation and the resulting activation of a nuclear receptor have also been proposed as a mechanism for tumor induction and for the immune and hormonal changes seen in rodents. However, it is not known if this mechanism is relevant to humans, where peroxisome proliferation is generally less apparent. Furthermore, new observations question whether this mechanism is specifically relevant to liver carcinogenesis in rodents. This issue remains a subject of active investigation.”20

research on humans

Two cross-sectional human studies observed a negative correlation of birth weight with serum levels of PFOA.21,22 Much of the research that suggested the harmful effects of elevated levels of PFOS and PFOA in humans comes from an environmental study of more than 60,000 people that was created in 2005 as part of a settlement agreement.20 This was sparked by a series of lawsuits in 2001 and 2002 that accused the DuPont chemical company of contaminating drinking water in the Ohio River Valley.23,20

That research found that people who’d been exposed to higher than normal levels of PFOA had an elevated risk of high cholesterol, ulcerative colitis, thyroid disease, testicular cancer, kidney cancer, and pregnancy-induced hypertension.23

Another study in 2013, investigating the relationship between PFOA exposure and cancer among residents living near the DuPont Teflon manufacturing plant in Parkersburg, West Virginia, suggests that higher PFOA serum levels may be associated with testicular, kidney, prostate, and ovarian cancers, as well as non-Hodgkin’s lymphoma.24

To avoid PFOAs during meal preparation, patients can consider cooking with stainless steel or cast iron. IFM has a wealth of information for clinicians to use as reference when talking to patients about chemicals and food preparation. For IFM members, these materials are printable and can be distributed to patients in the office: Non-Toxic Choices for Food Preparation, Cookware, and Dishes; A Guide to Cooking with Fats and Oils; and Cooking to Preserve Nutrition. 

Conclusion

It is the nature of the world we live in that chemicals are literally all around us—in the air we breathe, the food we consume, and the items we use for everyday life—but armed with knowledge, people can make choices that limit their exposure. We have learned a great deal in recent years about how toxins affect us, where they originate, and how to improve our ability to detoxify in a toxic world. Understanding toxicity and taking practical steps to improve biotransformation and elimination of toxicants are essential and critical pieces in any integrative approach to your patients’ health and well-being.

To learn more about toxins in our environment, consider the following IFM-authored articles:

Read about the human health effects of exposure to pesticides

How do herbicides and insecticides impact human health?

References 

  1. Cross AJ, Sinha R. Meat-related mutagens/carcinogens in the etiology of colorectal cancer. Environ Mol Mutagen. 2004;44(1):44-55. doi:10.1002/em.20030 
  2. Jägerstad M, Skog K. Genotoxicity of heat-processed foods. Mutat Res. 2005;574(1-2):156-172. doi:10.1016/j.mrfmmm.2005.01.030  
  3. Sugimura T, Wakabayashi K, Nakagama H, Nagao M. Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci. 2004;95(4):290-299. doi:10.1111/j.1349-7006.2004.tb03205.x 
  4. Lao JY, Xie SY, Wu CC, Bao LJ, Tao S, Zeng EY. Importance of dermal absorption of polycyclic aromatic hydrocarbons derived from barbecue fumes. Environ Sci Technol. 2018;52(15):8330-8338. doi:10.1021/acs.est.8b01689
  5. Tseng M, Satia JA. Diet and cancer. In: McQueen CA, ed. Comprehensive Toxicology. 2nd ed. Elsevier; 2010:433-448. doi:10.1016/B978-0-08-046884-6.01422-6 
  6. Ito N, Hasegawa R, Sano M, et al. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 1991;12(8):1503-1506. doi:10.1093/carcin/12.8.1503
  7. Shirai T, Tamano S, Sano M, Masui T, Hasegawa R, Ito N. Carcinogenicity of 20-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) in rats: dose response studies. Princess Takamatsu Symp. 1995;23:232-239.
  8. Zheng W, Lee SA. Well-done meat intake, heterocyclic amine exposure, and cancer risk. Nutr Cancer. 2009;61(4):437-446. doi:10.1080/01635580802710741
  9. John EM, Stern MC, Sinha R, Koo J. Meat consumption, cooking practices, meat mutagens, and risk of prostate cancer. Nutr Cancer. 2011;63(4):525-537. doi:10.1080/01635581.2011.539311 
  10. Bylsma LC, Alexander DD. A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutr J. 2015;14:125. doi:10.1186/s12937-015-0111-3 
  11. Le NT, Michels FA, Song M, et al. A prospective analysis of meat mutagens and colorectal cancer in the Nurses’ Health Study and Health Professionals Follow-up Study. Environ Health Perspect. 2016;124(10):1529-1536. doi:10.1289/EHP238
  12. National Cancer Institute. Chemicals in meat cooked at high temperatures and cancer risk. Reviewed July 11, 2017. Accessed June 27, 2019. https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/cooked-meats-fact-sheet#r1
  13. Connellan SJ. Lung diseases associated with hydrocarbon exposure. Respir Med. 2017;126:46-51. doi:10.1016/j.rmed.2017.03.021 
  14. Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J. Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci. 2007;99(2):366-394. doi:10.1093/toxsci/kfm128 
  15. Agency for Toxic Substances and Disease Registry. Per- and polyfluoroalkyl substances (PFAS) and your health. Centers for Disease Control and Prevention. Reviewed January 10, 2018. Accessed June 27, 2019. https://www.atsdr.cdc.gov/pfas/health-effects.html 
  16. Prevedouros K, Cousins IT, Buck RC, Korzeniowski SH. Sources, fate and transport of perfluorocarboxylates. Environ Sci Technol. 2006;40(1):32-44. doi:10.1021/es0512475 
  17. Kennedy GL Jr, Butenhoff JL, Olsen GW, et al. The toxicology of perfluorooctanoate. Crit Rev Toxicol. 2004;34(4):351-384. 
  18. US Environmental Protection Agency. Evaluating human health risks from exposure to perfluorooctanoic acid (PFOA): recommendations to the science advisory board’s PFOA review panel. February 10, 2005. Accessed July 8, 2019. https://yosemite.epa.gov/sab/sabproduct.nsf/ded77e69fc8ced288525711e006fe16b/$file/kropp-ewg.pdf 
  19. US Environmental Protection Agency. SAB review of EPA’s draft risk assessment of potential human health effects associated with PFOA and its salts. May 30, 2006. Accessed July 8, 2019. https://nepis.epa.gov/Exe/ZyNET.exe/901S0J00.TXT?ZyActionD=ZyDocument&Client=EPA&Index=2006+Thru+2010&Docs=&Query=&Time=&EndTime=&SearchMethod=1&TocRestrict=n&Toc=&TocEntry=&QField=&QFieldYear=&QFieldMonth=&QFieldDay=&IntQFieldOp=0&ExtQFieldOp=0&XmlQuery=&File=D%3A%5Czyfiles%5CIndex%20Data%5C06thru10%5CTxt%5C00000001%5C901S0J00.txt&User=ANONYMOUS&Password=anonymous&SortMethod=h%7C-&MaximumDocuments=1&FuzzyDegree=0&ImageQuality=r75g8/r75g8/x150y150g16/i425&Display=hpfr&DefSeekPage=x&SearchBack=ZyActionL&Back=ZyActionS&BackDesc=Results%20page&MaximumPages=1&ZyEntry=1&SeekPage=x&ZyPURL 
  20. Steenland K, Fletcher T, Savitz DA. Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA). Environ Health Perspect. 2010;118(8):1100-1108. doi:10.1289/ehp.0901827
  21. Apelberg BJ, Witter FR, Herbstman JB, et al. Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect. 2007;115(11):1670-1676. doi:10.1289/ehp.10334
  22. Fei C, McLaughlin JK, Lipworth L, Olsen J. Maternal levels of perfluorinated chemicals and subfecundity. Hum Reprod. 2009;24(5):1200-1205. doi:10.1093/humrep/den490 
  23. C8 Science Panel. Updated January 4, 2017. Accessed July 1, 2019. http://www.c8sciencepanel.org/prob_link.html
  24. Vieira VM, Hoffman K, Shin HM, Weinberg JM, Webster TF, Fletcher T. Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis. Environ Health Perspect. 2013;121(3):318-323. doi:

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