“The Challenges of Evidence-Based Medicine” with John P.A. Ioannidis, MD, DSc

“It is impossible to know with 100% certainty what the truth is in any research question,” writes John P.A. Ioannidis, MD, DSc, in his 2005 essay, “Why Most Published Research Findings Are False.”1

Learn about the challenges of evidence-based medicine for the conduct and interpretation of research in the 2018 free Grand Rounds video series, offered free to clinicians through IFM in collaboration with Cleveland Clinic Center for Functional Medicine. “How good is the quality of clinical evidence?” asks Dr. Ioannidis.

In his Grand Rounds lecture, Dr. Ioannidis evaluates various levels of evidence and explores the importance of quality, significance, reproducibility, and feasibility. He also explains the complexities related to nutrition and lifestyle research and lays the foundation for responsibly establishing the evidence in this area. Dr. Ioannidis is one of the top-cited research physicians in the world and is a professor of medicine, of health research and policy, of biomedical data science, and of statistics at Stanford University.

Keeping with tradition, Grand Rounds help clinicians stay up-to-date in evolving areas of clinical practice and research. They are an important teaching tool that should be part of every Functional Medicine practitioner’s continuing medical education as well as a tremendous resource for improving patient care.

The free Grand Rounds Lecture Series now includes the lecture by Dr. Ioannidis on the challenges of evidence-based medicine and a Q&A with Mark Hyman, MD, director of Cleveland Clinic Center for Functional Medicine and IFM board president of clinical affairs. Gain access to the Grand Rounds lecture series by clicking here.

Visit the Grand Rounds hub


Ioannidis JP. Why most published research findings are false. PLOS Med. 2005;2(8):e124. doi:10.1371/journal.pmed.0020124.

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