News & Insights

Functional Medicine News & Emerging Research

Insights
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Rates of Celiac Disease Continue to Rise Worldwide

In addition to rising diagnoses, the prevalence of undiagnosed celiac disease seems to have increased dramatically in the US in the last 50 years. In an IFM interview, renowned celiac researcher Alessio Fasano, MD, speaks with Patrick Hanaway, MD, on how research has impacted the estimated prevalence rates of celiac disease in the US.

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Understanding & Diagnosing Functional Dyspepsia

Because dyspepsia can manifest in a multitude of symptoms, clinicians are encouraged to look for red flags that are clinical indicators of a possible serious underlying condition. Yet on diagnostic work-up, only 20 to 30% of patients with dyspepsia are found to have frank diseases that account for their symptoms.

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Intestinal Permeability & Associated Diseases

Crohn’s disease and ulcerative colitis, collectively called inflammatory bowel disease (IBD), are immune-mediated conditions characterized by a chronic inflammation of the gut. Increased intestinal permeability has been shown to play a central role in the pathogenesis of IBD. What are the mechanisms by which intestinal permeability contributes to the pathophysiology of disease, and what can clinicians do about it?

Dietary changes, chronic alcohol consumption, stress, the use of antibiotics, and other environmental factors, as well as genetic factors, can lead to alterations in the gut microbiota, which in turn may induce intestinal inflammation and increase intestinal permeability. As clinicians, how can we help patients with dysbiotic microbiota?

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Gut Dysbiosis and Stress

Once thought to be extraneous to the body, stress is now seen as a symptom of gut dysbiosis. Learn strategies for resolving stress and gut-based diseases.

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How Cholera Research Uncovered Zonulin

Alessio Fasano, MD, was head of a research lab focused on cholera. How, then, did his lab discover zonulin, a mediator of intestinal permeability?

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The Importance of Digestion & Nutrition in Chronic Disease

Gastrointestinal dysfunction can wreak havoc throughout the body, and has been linked to allergies, arthritis, autoimmune disease, chronic fatigue, and more. How does proper nutrition and digestion influence chronic disease?

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Research in the Field of Neurogastroenterology

How do changes in the intestinal microbiota affect the brain? Learn about new research in the field of neurogastroenterology.

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Factors to Consider for IBS Patients Under Increased Stress

Bile absorption difficulties are common in patients with irritable bowel syndrome, as are anxiety and depression. When and how should treatment address these concerns?

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The Hygiene Hypothesis & Helminth Treatments With Parasitic Worms

Humans evolved with many parasites. At high doses, hookworm infection causes gastrointestinal symptoms and anemia, but in small doses, hookworms modulate the immune response, increasing immune tolerance. Read More
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Fasano’s Triad and the Trajectory of Autoimmunity

Over the past 20 years, increasing evidence supports Alessio Fasano’s theory that a single protein is critical for triggering autoimmune disorders.

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A Better Approach to Treating GERD

Taking an over-the-counter acid blocker for occasional heartburn symptoms may not be a big issue, but in practice, many patients with chronic reflux are prescribed acid blockers indefinitely. Research suggests that this long-term approach may have significant drawbacks.

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Improve Your Success Rate in Treating IBS

“There need to be studies done to help people get their lives back. You should be able to go out and have lunch with family and friends instead of worrying when this will hit you because there is no ‘if,’ it’s ‘when,’” said a patient from the 2016 Canadian Gastrointestinal Society Survey. What can Functional Medicine practitioners do to improve the quality of life and clinical outcomes for patients with IBS?

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